基本情況
趙登高，男，1982年生 ，湖南邵陽人，博士，副教授。
聯(lián)系方式
地址：廣東江門市東城村22號五邑大學(xué)藥學(xué)與食品工程學(xué)院，郵編：529020
電話：0750-3299391
E-mail：wyuchemzdg@126.com
教育經(jīng)歷
2008/09--2013/06， 蘭州大學(xué)，有機(jī)化學(xué)， 博士
2001/09--2005/06， 蘭州大學(xué)，化學(xué)，學(xué)士
科研方向
（1）天然活性成分的發(fā)現(xiàn)、結(jié)構(gòu)修飾與改造。
（2）新型蛋白降解劑的設(shè)計(jì)與合成。
發(fā)表論文
（1） Mo, H.; Liu, J.; Yin, T.; Cao, X.; Su, Z.; Zhao, D.-G.*; Ma, Y.-Y.*, Discovery of a Selective and Orally Bioavailable RET Degrader with Effectiveness in Various Mutations. J. Med. Chem. 2025, https://doi.org/10.1021/acs.jmedchem.4c01889.
（2） Zhao, D. G.*; Liu, J.; Su, Z.; Zou, W.; Zhou, Q.; Yin, T.; Jiyao, T.; Ma, Y. Y., * Discovery of novel KSP-targeting PROTACs with potent antitumor effects in vitro and in vivo. Euro. J. Med. Chem. 2025, 282, 117052.
（3） Mo, H.; Liu, J.; Su, Z.; Zhao, D. G.; Ma, Y. Y.; Zhang, K.; Wang, Q.; Fu, C.; Wang, Y.; Chen, M.; Hu, B., Isoalantolactone/hydroxamic acid hybrids as potent dual STAT3/HDAC inhibitors and self-assembled nanoparticles for cancer therapy. Euro. J. Med. Chem. 2024, 277, 116765. 2024.8
（4） Shu-Ting Li, Dan Xu, Jing Jia, Wenbo Zou, Jieying Liu, Yao Wang, Kun Zhang, Xi Zheng, Yan-Yan Ma*; Xuejian Zhang, Deng-Gao Zhao *, Structure and anti-inflammatory activity of neo-clerodane diterpenoids from Scutellaria barbata. Phytochemistry 2023, 213,113771.
（5） Mo, H.; Zhang, R.; Chen, Y.; Li, S.; Wang, Y.; Zou, W.; Lin, Q.; Zhao, D.-G. *; Du, Y. *; Zhang, K.; Ma, Y.-Y. *, Synthesis and anticancer activity of novel histone deacetylase inhibitors that inhibit autophagy and induce apoptosis. Euro. J. Med. Chem. 2022, 114705.
（6） Xuan He, Man Zhang, Shu-Ting Li, Xinyu Li, Qingrong Huang, Kun Zhang, Xi Zheng, Xue-Tao Xu, Deng- Gao Zhao*, Yan- Yan Ma*. Alteration of gut microbiota in high- fat diet- induced obese mice using carnosic acid from rosemary. Food Science & Nutrition, 2022, 00, 1– 8.
（7） Ruiqiang Zhang, Hualong Mo, Yan-Yan Ma, Deng-Gao Zhao*, Tingwen Zhang, Xue cheng Chen, Kun Zhang, Xi Zheng. Synthesis and structure-activity relationships of 5-phenyloxazole-2-carboxylic acid derivatives as novel inhibitors of tubulin polymerization. Bioorganic & Medicinal Chemistry Letters, 2021, 3, 127968.
（8） Yan-Yan Ma, Deng-Gao Zhao*, Ruiqiang Zhang, Xuan He, Bao Qiong Li, Xiang-Zhi Zhang, Zijian Wang and Kun Zhang*. Identification of bioactive compounds that contribute to the α-glucosidase inhibitory activity of rosemary. Food & Function, 2020, 11, 1692-1701.
